Scaler (also known as Scaler: The Shapeshifting Chameleon) revolves around the story of a 12-year-old, wise-cracking boy named Bobby Jenkins, who accidentally stumbles across his evil next door neighbor's (Looger) plot to dominate the world through use of mutant lizards from another dimension. Captured, they restrain him and strike him with a bolt of energy and transform him into his shape-shifting alter-ego, Scaler -- a vivid blue and yellow mutant lizard, packing razor sharp claws, a viciously long tongue, and the ability to shift into several other kinds of lizards to boot!
Interesting, though cliché as this plot may sound, this is only a piece of the puzzle. Earth is, apparently, a mere speck in the universe. The universe in turn, is a mere speck in the infinitely vast "Multiverse".
A network of unstable portals are the only connections between the different dimensions in said multiverse. Any being in control of these portals would have the ability to move freely between the different worlds, and unleashing Hell upon them. Unfortunately, Looger has managed to do just that through use of a device created by a scientist named Leon, who was sent spiraling through a portal to some desolate world. Bobby "Scaler" Jenkins is tossed through the portal by Looger and his lackeys as well, and must now travel the strange world in his new form, find, and defeat Looger -- lest the multiverse be "trashed".