The ultimate aim of the game is to collect three artifacts and to place each on its pedestal in the final zone. This allows ascension to the Cosmic Circle, where the player becomes a god. There are four main paths to proceed through the game: Allying with either the T'Rang or Umpani, allying with both, or else being enemies with both. In addition, players can also choose to gain friendship with the Rattkin or the Trynnie, and players can choose whether or not to ally with the Rapax, Rattkin Razuka or Mook (though none of these choices affect the ending of the game).
Each race and class has a balance of strengths and weaknesses. The various races and classes are designed to be balanced so that a wide variety of parties can be playable. Characters may change their class as they advance, allowing a variety of combinations.
Monsters are scaled to the party level; higher level parties will face different sets of monsters than a lower level party in the same area. The scaling is limited to allow variation in difficulty.
For players seeking a more difficult challenge, Sir-Tech brought back an option to play using rules from the early Wizardries - the "Iron Man Mode". In this "permadeath" mode, players are not allowed to save the game; instead the game is automatically saved when the player quits. As a result, a death cannot be trivially undone by a simple "Restore Game".
There are many secret areas, including "retro dungeons". Retro Dungeon refer to the look of the dungeons in the original Wizardry (Proving Grounds of the Mad Overlord). Instead of vast open views, players are greeted with a solid, traditional grid-based dungeon. Spinners, traps and teleporters are used.